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Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies

Chadeau-Hyam, M; Athersuch, TJ; Keun, HC; De Iorio, M; Ebbels, TMD; Jenab, M; Sacerdote, C; (2011) Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies. BIOMARKERS , 16 (1) 83 - 88. 10.3109/1354750X.2010.533285.

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Abstract

Background: Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies.Methods: Parallel statistical analysis of the correlation between H-1 NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed.Results: Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified.Conclusion: This implementation of the novel "meet-in-the-middle" analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease.

Type: Article
Title: Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies
DOI: 10.3109/1354750X.2010.533285
Keywords: cohort studies, metabonomics, nested design, metabolic profiles, intermediate biomarkers, URINARY-EXCRETION, NMR-SPECTROSCOPY, MEAT CONSUMPTION, CANCER-RESEARCH, BLOOD-SERUM, NUTRITION, PLASMA, TOXICOLOGY, DIET, METABONOMICS
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science
URI: http://discovery.ucl.ac.uk/id/eprint/1360528
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