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PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A(2) Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry

Casas, JP; Ninio, E; Panayiotou, A; Palmen, J; Cooper, JA; Ricketts, SL; Sofat, R; ... Talmud, PJ; + view all (2010) PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A(2) Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry. CIRCULATION , 121 (21) 2284 - U74. 10.1161/CIRCULATIONAHA.109.923383.

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Abstract

Background-Higher lipoprotein-associated phospholipase A2 (Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal.Methods and Results-A meta-analysis including a total of 12 studies (5 prospective, 4 case-control, 1 case-only, and 2 cross-sectional studies; n = 26 118) was undertaken to examine the association of the following: (1) Lp-PLA2 activity versus cardiovascular biomarkers and risk factors and CHD events (2 prospective studies; n = 4884); (2) PLA2G7 single-nucleotide polymorphisms and Lp-PLA2 activity (3 prospective, 2 case-control, 2 cross-sectional studies; up to n = 6094); and (3) PLA2G7 single-nucleotide polymorphisms and angiographic coronary artery disease (2 case-control, 1 case-only study; n = 4971 cases) and CHD events (5 prospective, 2 case-control studies; n = 5523). Lp-PLA2 activity correlated with several CHD risk markers. Hazard ratios for CHD events for the top versus bottom quartile of Lp-PLA2 activity were 1.61 (95% confidence interval, 1.31 to 1.99) and 1.17 (95% confidence interval, 0.91 to 1.51) after adjustment for baseline traits. Of 7 single-nucleotide polymorphisms, rs1051931 (A379V) showed the strongest association with Lp-PLA2 activity, with VV subjects having 7.2% higher activity than AAs. Genotype was not associated with risk markers, angiographic coronary disease (odds ratio, 1.03; 95% confidence interval, 0.80 to 1.32), or CHD events (odds ratio, 0.98; 95% confidence interval, 0.82 to 1.17).Conclusions-Unlike Lp-PLA2 activity, PLA2G7 variants associated with modest effects on Lp-PLA2 activity were not associated with cardiovascular risk markers, coronary atheroma, or CHD. Larger association studies, identification of single-nucleotide polymorphisms with larger effects, or randomized trials of specific Lp-PLA2 inhibitors are needed to confirm or refute a contributory role for Lp-PLA2 in CHD. (Circulation. 2010; 121: 2284-2293.)

Type: Article
Title: PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A(2) Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry
DOI: 10.1161/CIRCULATIONAHA.109.923383
Keywords: epidemiology, genetics, mendelian randomization analysis, risk factors, ACTIVATING-FACTOR-ACETYLHYDROLASE, PLASMA PAF-ACETYLHYDROLASE, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, ARTERY-DISEASE, ATHEROSCLEROTIC PLAQUE, GENE, MEN, DEFICIENCY, HAPLOTYPES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Centre for Cardiovascular Genetics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: http://discovery.ucl.ac.uk/id/eprint/136010
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