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Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains.

Andreazzoli, M; Gestri, G; Landi, E; D'Orsi, B; Barilari, M; Iervolino, A; Vitiello, M; ... Dente, L; + view all (2012) Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains. Biochimie , 94 (9) 2054 - 2057. 10.1016/j.biochi.2012.05.002. Green open access

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Abstract

We report the identification of a novel partner of Kidins220/ARMS (Kinase D-interacting substrate of 220 kDa/Ankyrin Repeat-rich Membrane Spanning) an adaptor of neurotrophin receptors playing crucial roles during neurogenesis. Screening a phage display library of brain cDNA products we found that D. rerio Pdzrn3, a protein containing RING-finger and PDZ-domains, interacts with Kidins220/ARMS through its first PDZ-domain. Both zebrafish proteins share high homology with the corresponding mammalian proteins and both genes are developmentally expressed in neural districts where early neurogenesis occurs. The interaction was also confirmed by biochemical assays and by co-localization at the tips of growing neurites of PC12 cells induced with nerve growth factor.

Type: Article
Title: Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains.
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biochi.2012.05.002
Publisher version: http://dx.doi.org/10.1016/j.biochi.2012.05.002
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Amino Acid Sequence, Animals, Carrier Proteins, Computational Biology, HEK293 Cells, Humans, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, PC12 Cells, Protein Binding, Protein Structure, Tertiary, Rats, Zebrafish Proteins
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1359761
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