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Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: Evidence from a US nationally representative sample

De Neve, J-E; (2011) Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: Evidence from a US nationally representative sample. Journal of Human Genetics , 56 (6) 456 - 459. 10.1038/jhg.2011.39.

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Abstract

Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case-control association study on a representative sample of Americans (N=2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P=0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness. © 2011 The Japan Society of Human Genetics All rights reserved.

Type:Article
Title:Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: Evidence from a US nationally representative sample
DOI:10.1038/jhg.2011.39
UCL classification:UCL > School of Arts and Social Sciences > Faculty of Social and Historical Sciences > Political Science

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