De Neve, J-E;
(2011)
Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample.
J Hum Genet
, 56
(6)
pp. 456-459.
10.1038/jhg.2011.39.
Abstract
Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case-control association study on a representative sample of Americans (N=2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P=0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness.
| Type: | Article |
|---|---|
| Title: | Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample. |
| Location: | England |
| DOI: | 10.1038/jhg.2011.39 |
| Keywords: | Adolescent, Adult, Alleles, Case-Control Studies, Gene Frequency, Genotype, Humans, Personal Satisfaction, Polymorphism, Genetic, Serotonin Plasma Membrane Transport Proteins, United States, Young Adult |
| UCL classification: | UCL > School of Arts and Social Sciences |
| URI: | http://discovery.ucl.ac.uk/id/eprint/1359517 |
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