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A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families.

Morley, KI; Medland, SE; Ferreira, MA; Lynskey, MT; Montgomery, GW; Heath, AC; Madden, PA; (2006) A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. Behavior genetics , 36 (1) pp. 87-99. 10.1007/s10519-005-9004-0.

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Abstract

Many twin studies have identified sex differences in the influence of genetic and environmental factors on smoking behaviors. We explore the evidence for sex differences for smoking initiation and cigarette consumption in a sample of Australian twin families, and extend these models to incorporate sex differences in linkage analyses for these traits. We further examine the impact of including or excluding non-smokers in genetic analyses of tobacco consumption. Accounting for sex differences improved linkage results in some instances. We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies.

Type: Article
Title: A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families.
DOI: 10.1007/s10519-005-9004-0
Publisher version: http://www.ncbi.nlm.nih.gov/pubmed/16365831
Additional information: file: :Users/kimorley/Documents/Mendeley/2006/Morley et al. - 2006 - Behavior genetics.pdf:pdf keywords: Adult,Aged,Aged, 80 and over,Analysis of Variance,Chromosome Mapping,Chromosomes, Human, Pair 11,Female,Genetic Predisposition to Disease,Humans,Male,Middle Aged,Phenotype,Queensland,Questionnaires,Smoking,Smoking: genetics,Tobacco Use Disorder,Tobacco Use Disorder: genetics,Twins, Dizygotic,Twins, Monozygotic pmid: 16365831
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
URI: http://discovery.ucl.ac.uk/id/eprint/1359293
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