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DETECTING GENE CONVERSION - PRIMATE VISUAL PIGMENT GENES

BALDING, DJ; NICHOLS, RA; HUNT, DM; (1992) DETECTING GENE CONVERSION - PRIMATE VISUAL PIGMENT GENES. P ROY SOC LOND B BIO , 249 (1326) 275 - 280.

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Abstract

The effects of gene conversion can be detected in the DNA sequences of multigene families. We develop a permutation test of the significance of patterns of sequence mismatches, and apply it to the sequences of the red- and green-sensitive visual pigment genes of human and the diana monkey. Whereas conventional tests of the rate of sequence divergence are equivocal, the permutation test convincingly excludes divergence in the absence of gene conversion (p = 10(-6)).

Type: Article
Title: DETECTING GENE CONVERSION - PRIMATE VISUAL PIGMENT GENES
Keywords: LINKED COLOR-VISION, MOLECULAR-GENETICS, POLYMORPHISM, EVOLUTION, MONKEYS, PHOTOPIGMENT, PHYLOGENY, ANCESTRY, GREEN, XQ28
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/135882
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