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Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.

Foley, P; Bradford, HF; Docherty, M; Fillit, H; Luine, VN; McEwen, B; Bucht, G; ... Hardy, J; + view all (1988) Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease. J Neurol , 235 (8) pp. 466-471.

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Abstract

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Type: Article
Title: Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.
Location: Germany
Keywords: Aged, Aged, 80 and over, Alzheimer Disease, Animals, Autoantibodies, Cerebral Cortex, Choline, Choline O-Acetyltransferase, Cholinergic Fibers, Humans, Middle Aged, Rats, Rats, Inbred Strains, Synaptosomes
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1357245
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