Lyons, PA and Rayner, TF and Trivedi, S and Holle, JU and Watts, RA and Jayne, DR and Baslund, B and Brenchley, P and Bruchfeld, A and Chaudhry, AN and Cohen Tervaert, JW and Deloukas, P and Feighery, C and Gross, WL and Guillevin, L and Gunnarsson, I and Harper, L and Hrušková, Z and Little, MA and Martorana, D and Neumann, T and Ohlsson, S and Padmanabhan, S and Pusey, CD and Salama, AD and Sanders, JS and Savage, CO and Segelmark, M and Stegeman, CA and Tesař, V and Vaglio, A and Wieczorek, S and Wilde, B and Zwerina, J and Rees, AJ and Clayton, DG and Smith, KG (2012) Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med , 367 (3) 214 - 223. 10.1056/NEJMoa1108735.
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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.
|Title:||Genetically distinct subsets within ANCA-associated vasculitis.|
|Keywords:||Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotyping Techniques, HLA-DP Antigens, Humans, Major Histocompatibility Complex, Male, Microscopic Polyangiitis, Myeloblastin, Polymorphism, Single Nucleotide, Risk Factors, Wegener Granulomatosis, alpha 1-Antitrypsin|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Internal Medicine|
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