UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Sex differences associated with primary biliary cirrhosis.

Smyk, DS; Rigopoulou, EI; Pares, A; Billinis, C; Burroughs, AK; Muratori, L; Invernizzi, P; (2012) Sex differences associated with primary biliary cirrhosis. Clin Dev Immunol , 2012 610504-. 10.1155/2012/610504. Gold open access

Abstract

Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to fibrosis and cirrhosis. The diagnostic hallmark of PBC is the presence of disease-specific antimitochondrial antibodies (AMA), which are pathognomonic for the development of PBC. The disease overwhelmingly affects females, with some cases of male PBC being reported. The reasons underlying the low incidence of males with PBC are largely unknown. Epidemiological studies estimate that approximately 7-11% of PBC patients are males. There does not appear to be any histological, serological, or biochemical differences between male and female PBC, although the symptomatology may differ, with males being at higher risk of life-threatening complications such as gastrointestinal bleeding and hepatoma. Studies on X chromosome and sex hormones are of interest when studying the low preponderance of PBC in males; however, these studies are far from conclusive. This paper will critically analyze the literature surrounding PBC in males.

Type: Article
Title: Sex differences associated with primary biliary cirrhosis.
Location: Egypt
Open access status: An open access publication
DOI: 10.1155/2012/610504
Keywords: Female, Humans, Liver Cirrhosis, Biliary, Male, Sex Factors
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1355984
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item