UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

Larhammar, D; Gustafsson, K; Claesson, L; Bill, P; Wiman, K; Schenning, L; Sundelin, J; ... Rask, L; + view all (1982) Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins. Cell , 30 (1) pp. 153-161.

Full text not available from this repository.

Abstract

Four cDNA clones, pDR-alpha-1, pDR-alpha-2, pDR-alpha-3 and pDR-alpha-4, corresponding to the alpha chain of HLA-DR antigens, have been sequenced. Restriction maps and sequences suggest that all clones are identical apart from a single-base substitution present in pDR-alpha-1. Amino acid sequence data, together with the nucleotide sequence data, allowed the complete amino acid sequence to be predicted. The alpha chain is composed of 229 amino acids, of which 191 are exposed on the outside of the plasma membrane. The membrane-embedded portion of the chain consists of 23 hydrophobic amino acids. The succeeding 15 amino acids form the cytoplasmically localized hydrophilic tail. The extracellular portion, with carbohydrate moieties linked to Asn78 and Asn118, seems to be organized into two domains. The second domain, which contains the only disulfide bond of the alpha chain, displays amino acid sequence homology to immunoglobulin constant regions, to the second domain of the beta chain of a class II antigen, to the third domain of heavy chains of class I antigens and to beta 2-microglobulin. Thus the subunits of immunoglobulins, class I antigens and class II antigens are related evolutionarily.

Type: Article
Title: Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.
Location: United States
Keywords: Amino Acid Sequence, Base Sequence, Cell Line, Chemical Phenomena, Chemistry, DNA, Genes, MHC Class II, HLA Antigens, HLA-B7 Antigen, HLA-DR Antigens, Histocompatibility Antigens Class II, Humans, Immunoglobulin Constant Regions, Immunoglobulins, Lymphocytes, beta 2-Microglobulin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/1354946
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item