Johansen, NB;
Vistisen, D;
Brunner, EJ;
Tabák, AG;
Shipley, MJ;
Wilkinson, IB;
McEniery, CM;
... Witte, DR; + view all
(2012)
Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study.
PLoS One
, 7
(5)
, Article e37165. 10.1371/journal.pone.0037165.
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Abstract
Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown.
| Type: | Article |
|---|---|
| Title: | Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0037165 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0037165 |
| Language: | English |
| Additional information: | PMCID: PMC3358295 © 2012 Johansen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Whitehall II study has been supported by grants from the Medical Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart Lung and Blood Institute (R01 HL36310), United States, National Institutes of Health (NIH): National Institute on Aging (R01 AG013196; R01 AG034454), United States, NIH; Agency for Health Care Policy Research (HS06516); and the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health. MK is supported by the Academy of Finland and the BUPA Foundation, UK. Measurements of IL-1Ra and adiponectin were funded by a Medical Research Council New Investigator Award (G0501184). CH and MR are supported by the Federal Ministry of Health (Berlin, Germany) and the Ministry of Innovation, Science, Research and Technology of the state North-Rhine Westphalia (Düsseldorf, Germany). IBW is a British Heart Foundation Senior Research Fellow, and CMM an Intermediate Fellow. Both are also supported by the Biomedical Research centre Award. NBJ is funded by an unrestricted grant from the European Foundation for the Study of Diabetes(EFSD)/Pfizer for Research into Cardiovascular Disease risk Reduction in Patients with Diabetes (74550801) (See funding program on www.europeandiabetesfoundation.org). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Adult, Aged, Aged, 80 and over, Aorta, Blood Flow Velocity, Blood Pressure, Cardiovascular Diseases, Cohort Studies, Female, Follow-Up Studies, Humans, Insulin Resistance, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Pulsatile Flow, Questionnaires, Risk Factors, Vascular Stiffness, Waist-Hip Ratio |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1354824 |
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