Walker, SM;
Grafe, M;
Yaksh, TL;
(2012)
Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity.
Anesthesia & Analgesia
, 115
(2)
450 - 460.
10.1213/ANE.0b013e3182501a09.
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Abstract
Neuraxial clonidine is used for perioperative analgesia in children of all ages. Preclinical studies in the postnatal rat allow comparison of the relative toxicity and safety of spinal analgesics throughout postnatal development.
| Type: | Article |
|---|---|
| Title: | Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1213/ANE.0b013e3182501a09 |
| Publisher version: | http://dx.doi.org/10.1213/ANE.0b013e3182501a09 |
| Language: | English |
| Keywords: | Age Factors, Analgesics, Animals, Animals, Newborn, Apoptosis, Behavior, Animal, Carrageenan, Clonidine, Disease Models, Animal, Dose-Response Relationship, Drug, Hyperalgesia, Injections, Spinal, Lumbosacral Region, Neuroglia, Pain, Pain Measurement, Pain Threshold, Rats, Rats, Sprague-Dawley, Reaction Time, Risk Assessment, Spinal Cord, Time Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1354244 |
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