UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania

Watson-Jones, D; Baisley, K; Rusizoka, M; Tanton, C; Mugeye, K; Weiss, HA; Changalucha, J; ... Hayes, RJ; + view all (2009) Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania. CONTEMP CLIN TRIALS , 30 (6) 504 - 512. 10.1016/j.cct.2009.07.002.

Full text not available from this repository.

Abstract

This study estimates adherence and identifies predictors of good adherence among 1305 Tanzanian women participating in a randomised, double-blind, placebo-controlled trial of HSV suppressive therapy to reduce HIV incidence or genital HIV shedding. Women were randomised to acyclovir 400 mg BD or placebo and followed every three months for 12-30 30 months. Adherence was assessed by tablet counts. Random urine samples, collected between 6 and 24 months, were tested for acyclovir. At 12, 24 and 30 month visits, 56%, 52% and 54% of women on treatment had adherence >= 90%, respectively. Factors independently associated with good adherence (taking >= 90% of tablets in the preceding 3-months) included older age, understanding trial concepts at enrolment, living >2 years in the screening site, receiving an unannounced tablet check visit, using oral contraception at screening, living in the same site and house as the previous visit, accessing VCT during the trial, recent malaria and not having a positive pregnancy test. Overall, 55% of urine samples from women randomised to acyclovir had detectable acyclovir. Additional, tailored adherence strategies may be needed for younger, more mobile women and those who have not used oral contraception, which may sensitise them to daily tablet-taking. Use of biomarkers may alert investigators to adherence problems. (C) 2009 Published by Elsevier Inc.

Type: Article
Title: Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania
DOI: 10.1016/j.cct.2009.07.002
Keywords: Acyclovir, Clinical trial, HSV-2, Patient compliance, Tanzania, HERPES-SIMPLEX-VIRUS, PLACEBO-CONTROLLED TRIAL, ANTIRETROVIRAL THERAPY, DOUBLE-BLIND, HIV ACQUISITION, RISK-FACTORS, WOMEN, ACYCLOVIR, INFECTION, DRUG
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/135416
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item