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Structural biology of the chaperone-usher pathway of pilus biogenesis

Waksman, G; Hultgren, SJ; (2009) Structural biology of the chaperone-usher pathway of pilus biogenesis. NAT REV MICROBIOL , 7 (11) 765 - 774. 10.1038/nrmicro2220.

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Abstract

The chaperone-usher (CU) pathway of pilus biogenesis is the most widespread of the five pathways that assemble adhesive pili at the surface of Gram-negative bacteria. Recent progress in the study of the structural biology of the CU pathway has unravelled the molecular basis of chaperone function and elucidated the mechanisms of fibre assembly at the outer membrane, leading to a comprehensive description of each step in the biogenesis pathway. Other studies have provided the molecular basis of host recognition by CU pili. The knowledge that has been gathered about both the assembly of and host recognition by CU pili has been harnessed to design promising antibiotic compounds.

Type: Article
Title: Structural biology of the chaperone-usher pathway of pilus biogenesis
DOI: 10.1038/nrmicro2220
Keywords: UROPATHOGENIC ESCHERICHIA-COLI, BACTERIAL OUTER-MEMBRANE, URINARY-TRACT-INFECTIONS, SUBUNIT COMPLEX RECOGNITION, BLADDER EPITHELIAL-CELLS, ASSEMBLY PLATFORM FIMD, GRAM-NEGATIVE BACTERIA, DRIVES FIBER FORMATION, DONOR-STRAND EXCHANGE, RECEPTOR-BINDING
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/135404
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