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Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.

Gandhi, S; Vaarmann, A; Yao, Z; Duchen, MR; Wood, NW; Abramov, AY; (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One , 7 (5) , Article e37564. 10.1371/journal.pone.0037564. Green open access

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Abstract

Parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. Mutations in the PINK1 gene cause an autosomal recessive form of Parkinson's disease. Loss of PINK1 function causes mitochondrial dysfunction, increased reactive oxygen species production and calcium dysregulation, which increases susceptibility to neuronal death in Parkinson's disease. The basis of neuronal vulnerability to dopamine in Parkinson's disease is not well understood.

Type: Article
Title: Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0037564
Publisher version: http://dx.doi.org/10.1371/journal.pone.0037564
Language: English
Additional information: © 2012 Gandhi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3360782 AYA is a Parkinson's UK Senior Research Fellow. SG was a Wellcome Trust Clinical Research Fellow. NWW, AYA and MD are supported by The Wellcome Trust/MRC strategic award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Animals, Apoptosis, Calcium, Disease Models, Animal, Dopamine, Dopaminergic Neurons, Humans, Membrane Potential, Mitochondrial, Mice, Mice, Knockout, Mitochondria, Mitochondrial Membrane Transport Proteins, Parkinson Disease, Protein Kinases, Reactive Oxygen Species
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1353818
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