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Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model

Bertrand, J; Laffont, CM; Mentre, F; Chenel, M; Comets, E; (2011) Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model. AAPS JOURNAL , 13 (3) pp. 390-404. 10.1208/s12248-011-9282-9.

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Type: Article
Title: Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model
DOI: 10.1208/s12248-011-9282-9
Keywords: Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, PHARMACOLOGY & PHARMACY, back-transformation mechanism, estimation algorithms, first-pass metabolism, genetic covariate, nonlinear mixed effects modeling, MIXED EFFECTS MODELS, RISPERIDONE, CYP2D6, AGENT
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1353485
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