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Mesenchymal stem cells and articular cartilage repair: clinical studies and future direction.

Punwar, S; Khan, WS; (2011) Mesenchymal stem cells and articular cartilage repair: clinical studies and future direction. Open Orthop J , 5 Suppl 2 296 - 301. 10.2174/1874325001105010296.

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Abstract

Cartilage is frequently injured but shows little capacity for repair. Current treatment options include the use of procedures that stimulate repair through the stimulation of subchondral bone marrow and result in the formation of fibrocartilage. There is considerable interest in the use of cell-based treatment strategies and there are limited studies describing the use of mesenchymal stem cells for cartilage repair with promising early results. This paper reviews the current treatment strategies for articular cartilage, describes use of mesenchymal stem cells for articular cartilage repair along with the results of clinical studies, and describes the future direction that these strategies are likely to take.

Type:Article
Title:Mesenchymal stem cells and articular cartilage repair: clinical studies and future direction.
Location:Netherlands
DOI:10.2174/1874325001105010296
Language:English
Additional information:PMCID: PMC3149861
Keywords:Cartilage repair, chondrogenesis, mesenchymal stem cells, osteoarthritis, tissue engineering.
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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