Kennard, L; Thanabalasundaram, G; Tailor, HD; Khan, WS; (2011) Advances and developments in the use of human mesenchymal stem cells - a few considerations. Open Orthop J , 5 (Suppl 2) 249 - 252. 10.2174/1874325001105010249.
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One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.
|Title:||Advances and developments in the use of human mesenchymal stem cells - a few considerations.|
|Additional information:||PMCID: PMC3149860|
|Keywords:||Ageing, bone marrow, donor, growth factors, mesenchymal stem cells, senescence.|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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