UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Advances and developments in the use of human mesenchymal stem cells - a few considerations.

Kennard, L; Thanabalasundaram, G; Tailor, HD; Khan, WS; (2011) Advances and developments in the use of human mesenchymal stem cells - a few considerations. Open Orthop J , 5 (Suppl 2) 249 - 252. 10.2174/1874325001105010249.

Full text not available from this repository.

Abstract

One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.

Type:Article
Title:Advances and developments in the use of human mesenchymal stem cells - a few considerations.
Location:Netherlands
DOI:10.2174/1874325001105010249
Language:English
Additional information:PMCID: PMC3149860
Keywords:Ageing, bone marrow, donor, growth factors, mesenchymal stem cells, senescence.
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

Archive Staff Only: edit this record