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The role of bioreactors in tissue engineering for musculoskeletal applications.

Oragui, E; Nannaparaju, M; Khan, WS; (2011) The role of bioreactors in tissue engineering for musculoskeletal applications. Open Orthop J , 5 Suppl 2 267 - 270. 10.2174/1874325001105010267.

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Abstract

Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. We discuss the role of bioreactors in tissue engineering and evaluate the principles of bioreactor design. We evaluate the methods of cell stimulation and review the bioreactors in common use today.

Type:Article
Title:The role of bioreactors in tissue engineering for musculoskeletal applications.
Location:Netherlands
DOI:10.2174/1874325001105010267
Language:English
Additional information:PMCID: PMC3149843
Keywords:Bioreactors, design, scaffolds, stimulation, tissue engineering.
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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