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Axonal integrity predicts cortical reorganisation following cervical injury

Freund, P; Wheeler-Kingshott, CA; Nagy, Z; Gorgoraptis, N; Weiskopf, N; Friston, K; Thompson, AJ; (2012) Axonal integrity predicts cortical reorganisation following cervical injury. Journal of Neurology, Neurosurgery & Psychiatry , 83 (6) 629 -637. 10.1136/jnnp-2011-301875. Green open access

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Abstract

Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment.

Type: Article
Title: Axonal integrity predicts cortical reorganisation following cervical injury
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2011-301875
Publisher version: http://dx.doi.org/10.1136/jnnp-2011-301875
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. PMCID: PMC3348614
Keywords: Adult, Aged, Axons, Case-control studies, Cerebral cortex, Cervical vertebrae, Demyelinating diseases, Diffusion Tensor Imaging, Humans, Magnetic Resonance Imaging, Male, Middle aged, Nerve degeneration, Nerve fibers, Myelinated, Neural pathways, Neuroimaging, Psychomotor performance, Pyramidal tracts, Spinal cord injuries
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School
URI: http://discovery.ucl.ac.uk/id/eprint/1352756
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