Brockmann, K and Hilker, R and Pilatus, U and Baudrexel, S and Srulijes, K and Magerkurth, J and Hauser, AK and Schulte, C and Csoti, I and Merten, CD and Gasser, T and Berg, D and Hattingen, E (2012) GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure. Neurology , 79 (3) 213 - 220. 10.1212/WNL.0b013e31825dd369.
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Abstract
To elucidate possible mechanisms leading to neurodegeneration in patients with glucocerebrosidase (GBA)-associated Parkinson disease (PD) using combined proton ((1)H) and phosphorus ((31)P) magnetic resonance spectroscopic imaging (MRSI) in vivo.
| Type: | Article |
|---|---|
| Title: | GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure. |
| Location: | United States |
| DOI: | 10.1212/WNL.0b013e31825dd369 |
| Language: | English |
| Keywords: | Adenosine Diphosphate, Adult, Age of Onset, Aged, Algorithms, Aspartic Acid, Brain Chemistry, Choline, Creatine, DNA, Energy Metabolism, Female, Glucosylceramidase, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Membranes, Middle Aged, Mitochondria, Nerve Degeneration, Neurons, Parkinson Disease, Phospholipids, Software |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Brain Repair and Rehabilitation |
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