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Cells of the synovium in rheumatoid arthritis - B cells

Mauri, C; Ehrenstein, MR; (2007) Cells of the synovium in rheumatoid arthritis - B cells. ARTHRITIS RES THER , 9 (2) , Article 205. 10.1186/ar2125. Gold open access

Abstract

There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cytokines and chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease.

Type: Article
Title: Cells of the synovium in rheumatoid arthritis - B cells
Open access status: An open access publication
DOI: 10.1186/ar2125
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC19067...
Keywords: COLLAGEN-INDUCED ARTHRITIS, CYCLIC CITRULLINATED PEPTIDE, ANTIBODIES INDUCE ARTHRITIS, TOLL-LIKE RECEPTORS, ANTIINFLAMMATORY ACTIVITY, AUTOIMMUNE ARTHRITIS, DEFICIENT MICE, SERUM TRANSFER, BACTERIAL-DNA, FC RECEPTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/135242
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