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Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs

Mauri, C; Carter, N; (2009) Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs. ARTHRITIS RES THER , 11 (4) , Article 237. 10.1186/ar2752.

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Abstract

Nature has provided the developing immune system with several checkpoints important for the maintenance of tolerance and the prevention of autoimmunity. The regulatory mechanisms operating in the periphery of the system are mediated by subsets of regulatory cells, now considered principal contributors to peripheral tolerance. Regulatory T cells (Tregs) have received titanic interest in the past decade, placing them at the centre of immunosuppressive reactions. However, it has become clearer that other immune suppressive cells inhibit auto-reactivity as effectively as Tregs. The function of Tregs and other regulatory cells in rheumatoid arthritis will be discussed in this review.

Type: Article
Title: Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs
DOI: 10.1186/ar2752
Keywords: COLLAGEN-INDUCED ARTHRITIS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, CD4 T-CELLS, TOLEROGENIC DENDRITIC CELLS, NECROSIS-FACTOR-ALPHA, ZONE B-CELLS, RHEUMATOID-ARTHRITIS, ORAL TOLERANCE, TGF-BETA, AUTOIMMUNE ENCEPHALOMYELITIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/135230
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