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Ceramide as an activator lipid of cathepsin D.

Heinrich, M; Wickel, M; Winoto-Morbach, S; Schneider-Brachert, W; Weber, T; Brunner, J; Saftig, P; ... Schütze, S; + view all (2000) Ceramide as an activator lipid of cathepsin D. Adv Exp Med Biol , 477 pp. 305-315. 10.1007/0-306-46826-3_33.

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We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMase deficient cells derived from Niemann-Pick patients show decreased CTSD activity that was reconstituted by transfection with A-SMase cDNA. Ceramide accumulation in cells derived from A-ceramidase defective Farber patients correlates with enhanced CTSD activity. These findings suggest that A-SMase-derived ceramide targets endolysosomal CTSD.

Type: Article
Title: Ceramide as an activator lipid of cathepsin D.
Location: United States
DOI: 10.1007/0-306-46826-3_33
Keywords: Amidohydrolases, Animals, Apoptosis, Cathepsin D, Cell Compartmentation, Cell Line, Transformed, Ceramidases, Ceramides, Cytokines, DNA, Complementary, Enzyme Activation, Fibroblasts, HeLa Cells, Humans, Isoenzymes, Lipid Metabolism, Lymphocytes, Lysosomes, Mice, Mice, Inbred C57BL, Mice, Knockout, Niemann-Pick Diseases, Recombinant Fusion Proteins, Second Messenger Systems, Sphingomyelin Phosphodiesterase, Tumor Cells, Cultured, U937 Cells
URI: http://discovery.ucl.ac.uk/id/eprint/1351927
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