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Lipid rafts in T cell signalling and disease

Jury, EC; Flores-Borja, F; Kabouridis, PS; (2007) Lipid rafts in T cell signalling and disease. [Review]. Seminars in Cell & Developmental Biology , 18 (5) 608 - 615. 10.1016/j.semcdb.2007.08.002. Green open access

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Abstract

Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform diverse functions. A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes. In T cells, lipid raft involvement was demonstrated in the early steps during T cell receptor (TCR) stimulation. Interestingly, recent evidence has shown that signalling in these domains differs in T cells isolated from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we discuss these findings and explore the potential of lipid rafts as targets for the development of a new class of agents to downmodulate immune responses and for the treatment of autoimmune diseases.

Type: Article
Title: Lipid rafts in T cell signalling and disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcdb.2007.08.002
Publisher version: http://dx.doi.org/10.1016/j.semcdb.2007.08.002
Language: English
Additional information: An Open Access Elsevier publication.
Keywords: Lipid rafts, T cell, lupus, autoimmunity, review, systemic-lupus-erythematosus, protein-tyrosine kinase, receptor zeta-chain, redox balance alterations, antigen receptor, plasma-membrane, immunological synapse, rheumatoid-arthritis, peripheral-blood, adapter protein
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/135188
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