Shah, MM; Hammond, RS; Hoffman, DA; (2010) Dendritic ion channel trafficking and plasticity. Trends Neurosci , 33 (7) 307 - 316. 10.1016/j.tins.2010.03.002.
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Dendritic ion channels are essential for the regulation of intrinsic excitability as well as modulating the shape and integration of synaptic signals. Changes in dendritic channel function have been associated with many forms of synaptic plasticity. Recent evidence suggests that dendritic ion channel modulation and trafficking could contribute to plasticity-induced alterations in neuronal function. In this review we discuss our current knowledge of dendritic ion channel modulation and trafficking and their relationship to cellular and synaptic plasticity. We also consider the implications for neuronal function. We argue that to gain an insight into neuronal information processing it is essential to understand the regulation of dendritic ion channel expression and properties.
|Title:||Dendritic ion channel trafficking and plasticity.|
|Open access status:||An open access version is available from UCL Discovery|
|Additional information:||PMCID: PMC2902701 This is the author’s version of a work that was accepted for publication in Trends in Neurosciences. A definitive version was subsequently published in Trends in Neurosciences, Volume 33, Issue 7, July 2010, Pages 307–316 http://dx.doi.org/10.1016/j.tins.2010.03.002|
|Keywords:||Animals, Dendrites, Ion Channel Gating, Ion Channels, Neuronal Plasticity, Neurons, Protein Processing, Post-Translational, Synapses|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology|
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