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Uptake and release of [3H]GABA by growth cones isolated from neonatal rat brain.

Gordon-Weeks, PR; Lockerbie, RO; Pearce, BR; (1984) Uptake and release of [3H]GABA by growth cones isolated from neonatal rat brain. Neurosci Lett , 52 (1-2) pp. 205-210.

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Abstract

A subcellular fraction highly enriched in neuronal growth cones was isolated from 5-day-old rat forebrain by a recently described method. The growth cone fraction was shown to have a sodium- and temperature-dependent, high-affinity (Km = 4.4 microM) uptake system for [3H]GABA. Electron microscopic autoradiography confirmed that this uptake was into growth cones since only these structures were heavily labelled with silver grains. High potassium induced the release of newly accumulated [3H]GABA from the growth cone fraction, about half of which was Ca2+-dependent. The presence of uptake and release systems for GABA in growth cones may simply reflect the development of growth cones into nerve terminals. Alternatively, these observations may indicate a role for neurotransmitter release in synaptogenesis.

Type: Article
Title: Uptake and release of [3H]GABA by growth cones isolated from neonatal rat brain.
Location: Ireland
Keywords: Animals, Animals, Newborn, Autoradiography, Brain, Rats, Synapses, gamma-Aminobutyric Acid
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1350539
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