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Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva.

Tovell, VE and Chau, CY and Khaw, PT and Bailly, M (2012) Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva. Invest Ophthalmol Vis Sci , 53 (8) 4682 - 4691. 10.1167/iovs.11-8577.

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Abstract

To evaluate the efficiency of Rac1 inhibition in preventing matrix contraction by Tenon's capsule fibroblasts.

Type:Article
Title:Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva.
Location:United States
DOI:10.1167/iovs.11-8577
Language:English
Keywords:Aminoquinolines, Blotting, Western, Cells, Cultured, Collagen, Conjunctiva, Enzyme Inhibitors, Extracellular Matrix, Fibroblasts, Humans, Matrix Metalloproteinases, Pyrimidines, RNA, Messenger, Real-Time Polymerase Chain Reaction, rac1 GTP-Binding Protein

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