Shahban, SA; Brown, RA; Bozec, L; Cheema, U; (2009) Enhancing the mechanical properties of collagen by photo-chemical cross-linking. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 96 - 96).

Preview

PDF v018supp02a096.pdf Available under License : See the attached licence file. Download (33kB)

Abstract

Cell survival within mechanically strong scaffolds is critical in the design of tissue engineered constructs. Collagen type I gels tend to be mechanically weak due to the low percentage of collagen with limited orientation and crosslinking. To enhance the properties of collagen type I gels we used the following approaches: a) plastically compress the collagen gel to increase the density and b) photochemically crosslink the gel using riboflavin as a photoinitiator and high intensity blue light. Following plastic compression both the collagen density and cell number increase 58-fold1. This study aims to assess mechanical properties and the degree of cell viability in different areas of the compressed gel following cross-linking. Patterns of cross-linking were also applied to induce anisotropic features to the gels

Download activity - last month

Export as JSONCSVXML

Download activity - last 12 months

Export as JSONXMLCSV

Downloads by country - last 12 months

Export as XMLCSVJSON

Archive Staff Only

View Item