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Differentiated MSCs seeded in a highly dense collagenous matrix produce novel biphasic Osteochondral constructs

Brady, M; Sivananthan, S; Warnke, P; Mudera, V; (2009) Differentiated MSCs seeded in a highly dense collagenous matrix produce novel biphasic Osteochondral constructs. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 8-10 July 2009, Universities of Glasgow & Strathclyde. (pp. 50 - 50). Green open access

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Abstract

Structural damage to both the articular cartilage and subchondral bone results in pain and disability for millions of people worldwide, representing a major clinical challenge. Being a hybrid of both bone and cartilage, requirements for osteochondral tissue engineering are more complex than previously investigated single tissue types. Novel methods of integrating bone and cartilage tissue constructs need to be explored. In this study, two hyper-hydrated collagen gels, containing osteogenic and chondrogenic cells, were integrated to create a biphasic osteochondral construct.

Type: Proceedings paper
Title: Differentiated MSCs seeded in a highly dense collagenous matrix produce novel biphasic Osteochondral constructs
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: Universities of Glasgow & Strathclyde
Dates: 08 Jul 2009 - 10 Jul 2009
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1348468
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