Moghadam, HK; Pointer, MA; Wright, AE; Berlin, S; Mank, JE; (2012) W chromosome expression responds to female-specific selection. Proc Natl Acad Sci U S A , 109 (21) 8207 - 8211. 10.1073/pnas.1202721109.
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The W chromosome is predicted to be subject to strong female-specific selection stemming from its female-limited inheritance and therefore should play an important role in female fitness traits. However, the overall importance of directional selection in shaping the W chromosome is unknown because of the powerful degradative forces that act to decay the nonrecombining sections of the genome. Here we greatly expand the number of known W-linked genes and assess the expression of the W chromosome after >100 generations of different female-specific selection regimens in different breeds of chicken and in the wild ancestor, the Red Jungle Fowl. Our results indicate that female-specific selection has a significant effect on W chromosome gene-expression patterns, with a strong convergent pattern of up-regulation associated with increased female-specific selection. Many of the transcriptional changes in the female-selected breeds are the product of positive selection, suggesting that selection is an important force in shaping the evolution of gene expression on the W chromosome, a finding consistent with both the importance of the W chromosome in female fertility and the haploid nature of the W. Taken together, these data provide evidence for the importance of the sex-limited chromosome in a female heterogametic species and show that sex-specific selection can act to preserve sex-limited chromosomes from degrading forces.
|Title:||W chromosome expression responds to female-specific selection.|
|Additional information:||PMCID: PMC3361381|
|Keywords:||Animal Husbandry, Animals, Chick Embryo, Chickens, Evolution, Molecular, Female, Male, Oviposition, Polymorphism, Genetic, Sex Chromosomes, Sex Preselection, Species Specificity|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Genetics, Evolution and Environment|
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