Ahmad, S; Hogwood, CEM; Tait, A; Tarrant, R; Smales, CM; Bracewell, DG; (2012) Determination of critical host cell protein components during the recovery of monoclonal antibodies. In: (Proceedings) Bioprocess International 2012.
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In this study we characterise the critical host cell protein components in terms of their persistence in a platform process for monoclonal antibody production. This is performed using 2D-polyacryamide gel electrophoresis and mass spectrometry analysis. Fed-batch cell culture and scale-down processing methodologies provide the basis to investigate the impact of both up and downstream process variables. This integrated approach is applied to null and producer cell lines.
|Title:||Determination of critical host cell protein components during the recovery of monoclonal antibodies|
|Event:||Bioprocess International 2012|
|Location:||Prague, Czech Republic|
|Dates:||2012-04-18 - 2012-04-19|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering|
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