Ahmad, S and Hogwood, CEM and Tait, A and Tarrant, R and Smales, CM and Bracewell, DG (2012) Determination of critical host cell protein components during the recovery of monoclonal antibodies. In: (Proceedings) Bioprocess International 2012.
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Abstract
In this study we characterise the critical host cell protein components in terms of their persistence in a platform process for monoclonal antibody production. This is performed using 2D-polyacryamide gel electrophoresis and mass spectrometry analysis. Fed-batch cell culture and scale-down processing methodologies provide the basis to investigate the impact of both up and downstream process variables. This integrated approach is applied to null and producer cell lines.
| Type: | Proceedings paper |
|---|---|
| Title: | Determination of critical host cell protein components during the recovery of monoclonal antibodies |
| Event: | Bioprocess International 2012 |
| Location: | Prague, Czech Republic |
| Dates: | 2012-04-18 - 2012-04-19 |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering |
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