Hill, M; Barrett, AN; White, H; Chitty, LS; (2012) Uses of cell free fetal DNA in maternal circulation. Best Pract Res Clin Obstet Gynaecol , 26 (5) 639 - 654. 10.1016/j.bpobgyn.2012.03.004.
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For over a decade, researchers have focused their attention on the development of non-invasive prenatal diagnosis tests based on cell-free fetal DNA circulating in maternal blood. With the possibility of earlier and safer testing, non-invasive prenatal diagnosis has the potential to bring many positive benefits to prenatal diagnosis. Non-invasive prenatal diagnosis for fetal sex determination for women who are carriers of sex-linked conditions is now firmly established in clinical practice. Other non-invasive prenatal diagnosis-based tests are set to follow, as future applications, such as the detection of single-gene disorders and chromosomal abnormalities, are now well within reach. Here, we review recent developments in non-invasive prenatal diagnosis for genetic conditions and chromosomal abnormalities, and provide an overview of research into ethical concerns, social issues and stakeholder view points.
|Title:||Uses of cell free fetal DNA in maternal circulation.|
|Keywords:||Chromosome Aberrations, DNA, Female, Fetus, Genetic Diseases, Inborn, Humans, Maternal-Fetal Exchange, Pregnancy, Prenatal Diagnosis, Sex Determination Analysis|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health|
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