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Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe hemophilia A in Iran.

Daliri, AAK; Haghparast, H; Mamikhani, J; (2009) Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe hemophilia A in Iran. Int J Technol Assess Health Care , 25 (4) pp. 584-587. 10.1017/S0266462309990420.

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Abstract

OBJECTIVE: The aim of this study was to assess the incremental cost-effectiveness of on-demand versus prophylactic hemophilia therapy in Iran from a third-party payers' perspective. METHODS: A retrospective chart review of twenty-five type A hemophiliacs who were treated in three hemophilia treatment centers was conducted. The patients were boys 0-9 years old receiving one of two treatments: (i) prophylaxis with concentrate at clinic; (ii) concentrate at clinic as on-demand. Fourteen boys received on-demand infusions for bleeding events, and eleven boys received infusions prophylaxis. Data were extracted from documents in the hemophilia treatment centers during a period of approximately 6 months. RESULTS: The patients receiving prophylactic treatment had fewer bleeding events each month (mean, 0.26 versus 2.74) but used more concentrate (225.31 versus 87.20 units/kg per month). Average monthly cost per patient in the prophylaxis group was approximately 1.9 times higher than in the on-demand group. Compared with on-demand infusion, prophylaxis costs 3,201,656 Rials (euro213.45) per bleeding event prevented. CONCLUSION: Prophylactic care markedly reduces the number of bleeding episodes, but at considerable cost.

Type: Article
Title: Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe hemophilia A in Iran.
Location: England
DOI: 10.1017/S0266462309990420
Keywords: Child, Child, Preschool, Coagulants, Cost-Benefit Analysis, Drug Administration Schedule, Factor VIII, Hemophilia A, Humans, Iran, Male, Retrospective Studies, Severity of Illness Index
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
URI: http://discovery.ucl.ac.uk/id/eprint/1347521
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