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Discovery of purinergic signalling, the initial resistance and current explosion of interest.

Burnstock, G; (2012) Discovery of purinergic signalling, the initial resistance and current explosion of interest. Br J Pharmacol , 167 (2) 238 - 255. 10.1111/j.1476-5381.2012.02008.x.

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Abstract

There has been a remarkable growth of papers published about purinergic signalling via ATP since 1972. I am most grateful to the wonderful PhD students and postdoctoral fellows who have worked with me over the years to pursue the purinergic hypothesis despite early opposition and to the many outstanding scientists around the world who are currently extending the story. Recently, therapeutic approaches to pathological disorders include the development of selective P1 and P2 receptor subtype agonists and antagonists, as well as of inhibitors of extracellular ATP breakdown and of ATP transport enhancers and inhibitors. Medicinal chemists are starting to develop small molecule purinergic drugs that are orally bioavailable and stable in vivo.

Type:Article
Title:Discovery of purinergic signalling, the initial resistance and current explosion of interest.
Location:England
DOI:10.1111/j.1476-5381.2012.02008.x
Language:English
Additional information:PMCID: PMC3481036
Keywords:Adenosine Triphosphate, Animals, Cell Communication, Ion Channels, Models, Molecular, Muscle, Smooth, Neurotransmitter Agents, Protein Conformation, Receptors, Purinergic, Research, Signal Transduction, Synaptic Transmission
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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