Mair, W;
Piper, MDW;
Partridge, L;
(2005)
Calories do not explain extension of life span by dietary restriction in Drosophila.
PLoS Biology
, 3
(7)
, Article e223. 10.1371/journal.pbio.0030223.
![[thumbnail of journal.pbio.0030223.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
journal.pbio.0030223.pdf Download (274kB) |
Abstract
Dietary restriction (DR) extends life span in diverse organisms, including mammals, and common mechanisms may be at work. DR is often known as calorie restriction, because it has been suggested that reduction of calories, rather than of particular nutrients in the diet, mediates extension of life span in rodents. We here demonstrate that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake. Reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food, and with yeast having a much greater effect per calorie than does sugar. Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species.
| Type: | Article |
|---|---|
| Title: | Calories do not explain extension of life span by dietary restriction in Drosophila |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pbio.0030223 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pbio.0030223 |
| Language: | English |
| Additional information: | © 2005 Mair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Natural-selection, Food restriction, Melanogaster, Longevity, Age, Reproduction, Rats, Mortality, Evolution, History |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/134714 |
Archive Staff Only
 |
View Item |
