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Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation.

Calvaruso, V; Dhillon, AP; Tsochatzis, E; Manousou, P; Grillo, F; Germani, G; Patch, D; (2012) Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation. J Gastroenterol Hepatol , 27 (7) pp. 1227-1232. 10.1111/j.1440-1746.2012.07136.x.

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Abstract

Current histological scoring systems do not subclassify cirrhosis. Computer-assisted digital image analysis (DIA) of Sirius Red-stained sections measures fibrosis morphologically producing a fibrosis ratio (collagen proportionate area [CPA]). CPA could have prognostic value within a disease stage, such as cirrhosis. The aim of the present study was to evaluate CPA in patients with recurrent hepatitis C virus (HCV) allograft cirrhosis and assess its relationship with hepatic venous pressure gradient (HVPG).

Type: Article
Title: Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation.
Location: Australia
DOI: 10.1111/j.1440-1746.2012.07136.x
Keywords: Biological Markers, Biopsy, Collagen, Hepatic Veins, Hepatitis C, Chronic, Humans, Kaplan-Meier Estimate, Liver, Liver Cirrhosis, Liver Transplantation, Prognosis, Prospective Studies, Recurrence, Severity of Illness Index, Venous Pressure
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1346246
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