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Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.

Jones, MW; Strickland, RA; Schumacher, FF; Caddick, S; Baker, JR; Gibson, MI; Haddleton, DM; (2012) Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides. Chem Commun (Camb) , 48 (34) 4064 - 4066. 10.1039/c2cc30259d.

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Abstract

The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.

Type:Article
Title:Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.
Location:England
DOI:10.1039/c2cc30259d
Language:English
Keywords:Animals, Calcitonin, Disulfides, Maleimides, Models, Molecular, Phenol, Polymerization, Polymers, Salmon, Sulfhydryl Compounds
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
UCL > VP Enterprise

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