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Stress, ageing and dementia

O'dwyer, AM; Orrell, MW; (1994) Stress, ageing and dementia. International Review of Psychiatry , 6 (1) pp. 73-83. 10.3109/09540269409025244.

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It is well established that stress causes neuroendocrine changes. In particular, the central role of the hypothalamic-pituitary-adrenal axis in the stress response, and the multiple effects of adrenal steroids on neuronal activity, structure and chemistry suggests that the hypothalamic-pituitary-adrenal axis may form a link between environmental stress and psychiatric disease. We review the evidence for a theoretical relationship suggesting that through abnormalities of the hypothalamic-pituitary-adrenal axis, potential mechanisms exist whereby stress and ageing may contribute to neuronal damage and dementia. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Type: Article
Title: Stress, ageing and dementia
DOI: 10.3109/09540269409025244
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1345267
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