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Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging

Mallik, C; Bandula, S; Rice, S; Atkinson, D; Taylor, S; Moon, J; Punwani, S; (2012) Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging. Presented at: ISMRM 2012, Melbourne, Australia.

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Abstract

Changes in the fractional volume of the extravascular, extracellular space (VEES) can be indicative of pathology. Equilibrium MRI (EQ-MRI) is a recently proposed technique to measure VEES, provided a constant concentration is reached between the contrast agent in the blood pool and tissue of interest. A pharmacokinetic model of a bolus and infusion protocol was devised to predict an optimal infusion rate and the time when equilibrium would be reached over a range of Ktrans values incorporating both diseased and healthy tissue. Pilot data collected in a control is indicative that equilibrium was reached in normal liver and muscle tissue.

Type: Conference item (UNSPECIFIED)
Title: Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging
Event: ISMRM 2012
Location: Melbourne, Australia
Dates: 07 May 2012 - 12 May 2012
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1345028
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