Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging.
Presented at: ISMRM 2012, Melbourne, Australia.
Changes in the fractional volume of the extravascular, extracellular space (VEES) can be indicative of pathology. Equilibrium MRI (EQ-MRI) is a recently proposed technique to measure VEES, provided a constant concentration is reached between the contrast agent in the blood pool and tissue of interest. A pharmacokinetic model of a bolus and infusion protocol was devised to predict an optimal infusion rate and the time when equilibrium would be reached over a range of Ktrans values incorporating both diseased and healthy tissue. Pilot data collected in a control is indicative that equilibrium was reached in normal liver and muscle tissue.
|Type:||Conference item (UNSPECIFIED)|
|Title:||Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging|
|Dates:||07 May 2012 - 12 May 2012|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics
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