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Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging

Mallik, C; Bandula, S; Rice, S; Atkinson, D; Taylor, S; Moon, J; Punwani, S; (2012) Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging. In: (Proceedings) ISMRM 2012. (pp. 4085 - ?).

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Abstract

Changes in the fractional volume of the extravascular, extracellular space (VEES) can be indicative of pathology. Equilibrium MRI (EQ-MRI) is a recently proposed technique to measure VEES, provided a constant concentration is reached between the contrast agent in the blood pool and tissue of interest. A pharmacokinetic model of a bolus and infusion protocol was devised to predict an optimal infusion rate and the time when equilibrium would be reached over a range of Ktrans values incorporating both diseased and healthy tissue. Pilot data collected in a control is indicative that equilibrium was reached in normal liver and muscle tissue.

Type:Proceedings paper
Title:Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging
Event:ISMRM 2012
Location:Melbourne, Australia
Dates:2012-05-07 - 2012-05-12
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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