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Genetic determinants of lipid homeostasis.

Young, EH; Papamarkou, T; Wainwright, NW; Sandhu, MS; (2012) Genetic determinants of lipid homeostasis. Best Pract Res Clin Endocrinol Metab , 26 (2) 203 - 209. 10.1016/j.beem.2011.11.004.

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Abstract

Circulating levels of blood lipids are heritable risk factors for atherosclerosis and heart disease, and are the target of therapeutic intervention. Studies of monogenic disorders and - more recently - genome-wide association studies have identified several important genetic determinants of blood lipid levels. These have the potential to provide new drug targets to alter blood lipid levels and may improve prediction of cardiovascular disease. Better functional validation of lipid loci is required to clarify the biological role of proteins encoded by specific genomic regions and understand how they influence lipid metabolism and confer disease risk.

Type:Article
Title:Genetic determinants of lipid homeostasis.
Location:Netherlands
DOI:10.1016/j.beem.2011.11.004
Language:English
Keywords:Coronary Artery Disease, Genome-Wide Association Study, Homeostasis, Humans, Lipid Metabolism, Lipids, Polymorphism, Single Nucleotide, Risk
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science

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