Crompton, M and Costi, A and Hayat, L (1987) Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria. Biochem J , 245 (3) 915 - 918.
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Abstract
Rat heart mitochondria became permeabilized to sucrose when incubated with 100 nmol of Ca2+/mg of protein in the presence of Pi. Ca2+ chelation with EGTA restored impermeability to sucrose, which became entrapped in the matrix space. t-Butylhydroperoxide markedly promoted permeabilization in the presence of Ca2+ but not in its absence, and Ca2+-plus-t-butylhydroperoxide-induced permeabilization was reversed by EGTA. The data suggest that Ca2+ and oxidative stress synergistically promote the reversible opening of an inner membrane pore.
| Type: | Article |
|---|---|
| Title: | Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria. |
| Location: | ENGLAND |
| Language: | English |
| Additional information: | PMCID: PMC1148218 |
| Keywords: | Animals, Calcium, Egtazic Acid, Indicators and Reagents, Intracellular Membranes, Male, Mitochondria, Heart, Onium Compounds, Organophosphorus Compounds, Oxygen, Permeability, Peroxides, Rats, Rats, Inbred Strains, tert-Butylhydroperoxide |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) |
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