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Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria.

Crompton, M; Costi, A; Hayat, L; (1987) Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria. Biochem J , 245 (3) pp. 915-918.

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Abstract

Rat heart mitochondria became permeabilized to sucrose when incubated with 100 nmol of Ca2+/mg of protein in the presence of Pi. Ca2+ chelation with EGTA restored impermeability to sucrose, which became entrapped in the matrix space. t-Butylhydroperoxide markedly promoted permeabilization in the presence of Ca2+ but not in its absence, and Ca2+-plus-t-butylhydroperoxide-induced permeabilization was reversed by EGTA. The data suggest that Ca2+ and oxidative stress synergistically promote the reversible opening of an inner membrane pore.

Type: Article
Title: Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria.
Location: ENGLAND
Keywords: Animals, Calcium, Egtazic Acid, Indicators and Reagents, Intracellular Membranes, Male, Mitochondria, Heart, Onium Compounds, Organophosphorus Compounds, Oxygen, Permeability, Peroxides, Rats, Rats, Inbred Strains, tert-Butylhydroperoxide
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1344276
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