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The Regulation of Mitochondrial Calcium Transport in Heart

Crompton, M; (1985) The Regulation of Mitochondrial Calcium Transport in Heart. Current Topics in Membranes and Transport , 25 (C) pp. 231-276. 10.1016/S0070-2161(08)60769-8.

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This chapter describes the Ca 2+ uniporter, the Na+–Ca 2+ carrier, the Na+–H+ antiporter, Ca 2+ recycling, the kinetic regulation of mitochondrial Ca 2+ , the effects of catecholamines and glucagon on Ca 2+ transport by isolated mitochondria, and the regulation of mitochondrial Ca 2+ by catecholamines in vivo. The chapter provides the evidence that Ca 2+ cycle indeed operates and examines its steady state behavior, particularly under the influence of hormones that induce a change in mitochondrial Ca 2+ . Emphasis is placed on the properties and control of the Ca 2+ cycle in heart mitochondria. Transport systems of heart mitochondria are characterized, which appear to achieve such a tight regulation by mediating steady-state Ca 2+ cycling across the inner membrane. The principal physiological regulators of cardiac muscle contractility are noradrenaline released from sympathetic nerves and circulating catecholamines. The Ca 2+ cycle in heart may provide one means of coordinating energy expenditure and oxidative metabolism. While no de-amplification mechanism has been recognized in heart that would depress the relay response to cytosolic Ca 2+ during β-adrenergic stimulation, Na + –Ca 2+ carrier activation, demonstrated in liver mitochondria, would provide such control, but to date this mechanism has not been demonstrated in heart. © 1985, Elsevier Inc. All rights reserved.

Type: Article
Title: The Regulation of Mitochondrial Calcium Transport in Heart
DOI: 10.1016/S0070-2161(08)60769-8
URI: http://discovery.ucl.ac.uk/id/eprint/1344265
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