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Ca-dependent inhibition by trifluoperazine of the Na-Ca carrier in mitoplasts derived from heart mitochondria

Hayat, LH; Crompton, M; (1985) Ca-dependent inhibition by trifluoperazine of the Na-Ca carrier in mitoplasts derived from heart mitochondria. FEBS Letters , 182 (2) 281 - 286. 10.1016/0014-5793(85)80316-1.

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Abstract

The interaction of trifluoperazine and extramitochondrial Ca with the heart mitochondrial Na-Ca carrier has been investigated. External Ca inhibits the carrier equally in mitochondria and mitoplasts in which the outer membrane is lysed. Sensitivity to Ca is not removed by washing mitoplasts under varied conditions. Trifluoperazine is a potent inhibitor of the carrier in mitoplasts but not in mitochondria. Trifluoperazine inhibition in mitoplasts depends markedly on the presence of extramitochondrial Ca (2 μM). © 1985.

Type: Article
Title: Ca-dependent inhibition by trifluoperazine of the Na-Ca carrier in mitoplasts derived from heart mitochondria
DOI: 10.1016/0014-5793(85)80316-1
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1344264
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