UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The development of a stable, coated pellet formulation of a water-sensitive drug, a case study: Development of a stable core formulation

Fitzpatrick, S; Taylor, S; Booth, SW; Newton, MJ; (2006) The development of a stable, coated pellet formulation of a water-sensitive drug, a case study: Development of a stable core formulation. Pharmaceutical Development and Technology , 11 (4) 521 - 528. 10.1080/10837450600941079.

Full text not available from this repository.

Abstract

A development program has been carried out to provide a stable extrusion/spheronisation pellet formulation for a highly water-soluble drug, sitagliptin, which undergoes a change in physical form on processing and is subject to hydrolytic decomposition. A conventional extrusion/spheronization formulation resulted in significant degradation of the drug. The inclusion of glyceryl monostearate into the formulation was found to reduce the water levels required to such a level that there was no significant degradation of the drug during processing to form pellets. The use of a ram extruder to screen formulations with small quantities minimizes the need for the drug in the formulation-screening process, and the results from this method of extrusion were found to be translatable to the use of a screen extruder, which allowed scale-up of the process. Copyright © Informa Healthcare.

Type:Article
Title:The development of a stable, coated pellet formulation of a water-sensitive drug, a case study: Development of a stable core formulation
DOI:10.1080/10837450600941079
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

Archive Staff Only: edit this record