Milojevic, S;
Newton, JM;
Cummings, JH;
Gibson, GR;
Bothman, RL;
Ring, SG;
Allwood, MC;
(1995)
Amylose, the new perspective in oral drug delivery to the human large intestine.
S.T.P. Pharma Sciences
, 5
(1)
pp. 47-53.
Abstract
The possibility of drug targeting to the colon by using a coating comprising amylose in glassy form has been studied. Amylose is a naturally-occurring polysaccharide and possesses the ability to form gels and films. This ability has been used to formulate a coating by spraying it on to drugs in pellet form. However, amylose film strength is poor in water due to swelling and, under simulated gastro-intestinal conditions, allows drug release. With the incorporation of Ethocel® into the coat, drug release in vitro was suppressed over a period of 12 h. Further evaluation of the drug coated pellets was carried out in vitro in a batch culture fermenter containing foecal inoculum, simulating large bowel conditions. The coating was fermented and the drug released. The in vivo performance of coated 13 C glucose pellets in eight healthy human volunteers was evaluated using gamma scintigraphy and 13 CO 2 excretion in breath. Gamma scan photographs showed the mean arrival time of the pellets to be 3.5 h in the coecum (range 2.5 to 4.7 h). Breath 13 CO 2 was detected 3.7 h post-dosing and was not significant (1% recovery) until 6.4 h. Breath 13 CO 2 was not apparent before pellets had reached the coecum, with a delay of 2.9 h between coecum arrival and significant 13 CO 2 release.
| Type: | Article |
|---|---|
| Title: | Amylose, the new perspective in oral drug delivery to the human large intestine |
| UCL classification: | UCL > School of Life and Medical Sciences UCL > School of Life and Medical Sciences > Faculty of Life Sciences UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | http://discovery.ucl.ac.uk/id/eprint/1343740 |
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