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Amylose, the new perspective in oral drug delivery to the human large intestine

Milojevic, S; Newton, JM; Cummings, JH; Gibson, GR; Bothman, RL; Ring, SG; Allwood, MC; (1995) Amylose, the new perspective in oral drug delivery to the human large intestine. S.T.P. Pharma Sciences , 5 (1) pp. 47-53.

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Abstract

The possibility of drug targeting to the colon by using a coating comprising amylose in glassy form has been studied. Amylose is a naturally-occurring polysaccharide and possesses the ability to form gels and films. This ability has been used to formulate a coating by spraying it on to drugs in pellet form. However, amylose film strength is poor in water due to swelling and, under simulated gastro-intestinal conditions, allows drug release. With the incorporation of Ethocel® into the coat, drug release in vitro was suppressed over a period of 12 h. Further evaluation of the drug coated pellets was carried out in vitro in a batch culture fermenter containing foecal inoculum, simulating large bowel conditions. The coating was fermented and the drug released. The in vivo performance of coated 13 C glucose pellets in eight healthy human volunteers was evaluated using gamma scintigraphy and 13 CO 2 excretion in breath. Gamma scan photographs showed the mean arrival time of the pellets to be 3.5 h in the coecum (range 2.5 to 4.7 h). Breath 13 CO 2 was detected 3.7 h post-dosing and was not significant (1% recovery) until 6.4 h. Breath 13 CO 2 was not apparent before pellets had reached the coecum, with a delay of 2.9 h between coecum arrival and significant 13 CO 2 release.

Type: Article
Title: Amylose, the new perspective in oral drug delivery to the human large intestine
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: http://discovery.ucl.ac.uk/id/eprint/1343740
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