The assessment of the scale-up performance of the extrusion/spheronisation process.
International Journal of Pharmaceutics
The ability to predict the spheronisation performance of a standard extrudate over a 125-fold range has been assessed in terms of spheroid quality produced. It has been found possible to predict the performance of a 25 kg batch on a 65.6 cm diameter production spheroniser from experiments (with a 22.9 cm diameter laboratory spheroniser). To achieve such prediction it is necessary to use a good quality extrudate and operate the spheroniser at rotational speeds which give the same linear peripheral velocity of the plate. © 1995.
|Title:||The assessment of the scale-up performance of the extrusion/spheronisation process|
|Keywords:||Extrusion/spheronisation, Roundness, Scale-up|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
Archive Staff Only