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The assessment of the scale-up performance of the extrusion/spheronisation process

Newton, JM; Chapman, SR; Rowe, RC; (1995) The assessment of the scale-up performance of the extrusion/spheronisation process. International Journal of Pharmaceutics , 120 (1) 95 - 99. 10.1016/0378-5173(94)00425-5.

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Abstract

The ability to predict the spheronisation performance of a standard extrudate over a 125-fold range has been assessed in terms of spheroid quality produced. It has been found possible to predict the performance of a 25 kg batch on a 65.6 cm diameter production spheroniser from experiments (with a 22.9 cm diameter laboratory spheroniser). To achieve such prediction it is necessary to use a good quality extrudate and operate the spheroniser at rotational speeds which give the same linear peripheral velocity of the plate.

Type:Article
Title:The assessment of the scale-up performance of the extrusion/spheronisation process
DOI:10.1016/0378-5173(94)00425-5
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

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