Mullon, C;
Pomiankowski, A;
Reuter, M;
(2012)
Molecular evolution of Drosophila Sex-lethal and related sex determining genes.
BMC Evolutionary Biology
, 12
, Article 5. 10.1186/1471-2148-12-5.
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Abstract
Sex determining mechanisms are evolutionarily labile and related species often use different primary signals and gene regulatory networks. This is well illustrated by the sex determining cascade of Drosophila fruitflies, which have recruited Sex-lethal as the master switch and cellular memory of sexual identity, a role performed in other insects by the gene transformer. Here we investigate the evolutionary change in the coding sequences of sex determining genes associated with the recruitment of Sex-lethal. We analyze sequences of Sex-lethal itself, its Drosophila paralogue sister-or-Sex-lethal and downstream targets transformer and doublesex.
| Type: | Article |
|---|---|
| Title: | Molecular evolution of Drosophila Sex-lethal and related sex determining genes. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2148-12-5 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2148-12-5 |
| Language: | English |
| Additional information: | © 2012 Mullon et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3292462 |
| Keywords: | Animals, Drosophila Proteins, Drosophila melanogaster, Evolution, Molecular, Female, Insect Proteins, Male, Muscidae, RNA-Binding Proteins, Sex Determination Processes, Tephritidae |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1343133 |
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