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Targeting the visceral purinergic system for pain control

Burnstock, G; (2012) Targeting the visceral purinergic system for pain control. Current Opinion in Pharmacology , 12 (1) 80 - 86. 10.1016/j.coph.2011.10.008.

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Abstract

Experimental evidence is presented to support the hypothesis that purinergic mechanosensory transduction can initiate visceral pain in urinary bladder, ureter, gut and uterus. In general, physiological reflexes are mediated via P2X3 and P2X2/3 receptors on low threshold sensory fibres, while these receptors on high threshold sensory fibres mediate pain. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by purinergic agents, including P2X3 and P2X2/3 receptor antagonists that are orally bioavailable and stable in vivo and agents that modulate ATP release and breakdown. © 2011 Elsevier Ltd. All rights reserved.

Type:Article
Title:Targeting the visceral purinergic system for pain control
DOI:10.1016/j.coph.2011.10.008
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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