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Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.

Pang, DX; Smith, AJ; Humphries, SE; (2013) Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. Nutr Metab Cardiovasc Dis , 23 (6) 550 - 556. 10.1016/j.numecd.2011.12.012.

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Abstract

Common non-coding variations within the TCF7L2 locus have a strong influence on type 2 diabetes (T2D) susceptibility through uncharacterised mechanisms. An islet-specific functional polymorphism has been identified, although this does not explain the association between genotype and gene expression in other cell types. This study sought to identify these other functional TCF7L2 variants.

Type:Article
Title:Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.
Location:Netherlands
DOI:10.1016/j.numecd.2011.12.012
Language:English
Additional information:PMCID: PMC3778915
Keywords:Alleles, Alternative Splicing, Cell Line, Tumor, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Exons, Gene Expression, Genetic Predisposition to Disease, Homozygote, Humans, Leukocytes, Mononuclear, Polymorphism, Single Nucleotide, RNA, Messenger, Risk Factors, Transcription Factor 7-Like 2 Protein
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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