Pang, DX; Smith, AJ; Humphries, SE; (2013) Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. Nutr Metab Cardiovasc Dis , 23 (6) 550 - 556. 10.1016/j.numecd.2011.12.012.
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Common non-coding variations within the TCF7L2 locus have a strong influence on type 2 diabetes (T2D) susceptibility through uncharacterised mechanisms. An islet-specific functional polymorphism has been identified, although this does not explain the association between genotype and gene expression in other cell types. This study sought to identify these other functional TCF7L2 variants.
|Title:||Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.|
|Additional information:||PMCID: PMC3778915|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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